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nesako
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#276 2018-07-10 15:54

Re: DNP Pradžiamokslis

fitnesas rašė:

nesako rašė:

fitnesas rašė:

Jo as ir nezadu skubet,zadu pries dnp iskart uzdepleetint,kad net ir low doe naudos iskart duotu smile

Kuo maziau glikogeno like tuo maziau prakaitas musa ir karsta

Tiksliau kuo maziau angliu valgai. Pradzioj isdepleetina tavo glikogena,kad eitu riebala imt energijai. O poto ir anglis kuriuos valgai isdegina tai jei nevalgysi tai ir neprakaituosi tiek smile kaip su trenu panasiai cia kiek skaiciau

Jop . Lb panasus i trena dnp . Mane saltis kreto nuo treno jei mazai angliu kaip nzn kas . Dnp pries 600 mg irgi i gala pora d buvo jau saltoka lauke kai papusdavo vejas ir prakaitavimo nsktinio neliko

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fitnesas
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#277 2018-07-10 16:00

Re: DNP Pradžiamokslis

As trena laikiau 100mg ed ir nuostabu buvo neprakaituot naktim ir puikiai miegot,nes angliu low ir jie tik ryte ir po sales su greitais anglim tai viskas i raumenis sueina,nelieka jokio excesso deginimui tai karstis nemusdavo smile

P.s. pamenu pirma karta su trenu tai valgiau labai daug visko,tai nakti prabusdavau 10 kartu,kaldra apversdavom nes slapia ir kas nakti keist patalyne. Ir miegas sudinas buvo

Paskutinį kartą taisė fitnesas (2018-07-10 16:03)

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nesako
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#278 2018-07-10 16:20

Re: DNP Pradžiamokslis

utiutiu , kad pazysti veikianti trena . Nes kai pasakau , kad nuo treno kcal minuse salta but gali tai dauguma snuki toki suraukia kad bbd:d tai toks ju ten ir trenas zinai

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fitnesas
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#279 2018-07-10 16:28

Re: DNP Pradžiamokslis

Nu ir is formos gerai matosi treno poveikis big_smile aisku jei suda valgysi tai niekas nepades

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nesako
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#280 2018-07-10 16:38

Re: DNP Pradžiamokslis

fitnesas rašė:

Nu ir is formos gerai matosi treno poveikis big_smile aisku jei suda valgysi tai niekas nepades

Nesimato jei testo dahuja ir e2 nesuvaldytas :dd

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Savage
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#281 2018-07-10 16:52

Re: DNP Pradžiamokslis

nesako rašė:

utiutiu , kad pazysti veikianti trena . Nes kai pasakau , kad nuo treno kcal minuse salta but gali tai dauguma snuki toki suraukia kad bbd:d tai toks ju ten ir trenas zinai

Zinau gera atmaza-neimlus nandrolonam,nu cia tas kur dabar purto pripasakojo

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fitnesas
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#282 2018-07-10 17:40

Re: DNP Pradžiamokslis

Jo cia tai sugalvojo big_smile nejautrus trenui, utiutiu kai semkas xujarini ir utiutiu. Ar tipo kenkia taip pat sveikatai tik netasko raumenu? big_smile

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Savage
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#283 2018-07-10 17:43

Re: DNP Pradžiamokslis

fitnesas rašė:

Jo cia tai sugalvojo big_smile nejautrus trenui, utiutiu kai semkas xujarini ir utiutiu. Ar tipo kenkia taip pat sveikatai tik netasko raumenu? big_smile

Superhuman no sides  no nothing

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fitnesas
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#284 2018-07-10 17:45

Re: DNP Pradžiamokslis

Bunk gear greiciau 🤣

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Savage
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#285 2018-07-10 17:49

Re: DNP Pradžiamokslis

fitnesas rašė:

Bunk gear greiciau 🤣

Lazda turi 2 galus 😊😊

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sidaz
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#286 2018-08-09 20:45

Re: DNP Pradžiamokslis

Kam nors d np nudažo delnus ir krūtinę? 😂

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Savage
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#287 2018-08-09 20:53

Re: DNP Pradžiamokslis

sidaz rašė:

Kam nors d np nudažo delnus ir krūtinę? 😂

Sperma ir,nu as nebandes bet sake sperma zalia

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nesako
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#288 2018-08-09 21:03

Re: DNP Pradžiamokslis

Garmus rašė:

sidaz rašė:

Kam nors d np nudažo delnus ir krūtinę? 😂

Sperma ir,nu as nebandes bet sake sperma zalia

Geltona. Ne zalia

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Savage
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#289 2018-08-09 21:16

Re: DNP Pradžiamokslis

Nu jo

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sidaz
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#290 2018-09-18 15:47

Re: DNP Pradžiamokslis

Gal ką išbėrė buvo visa kaktą?

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Mighti
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#291 2018-09-18 15:52

Re: DNP Pradžiamokslis

sidaz rašė:

Gal ką išbėrė buvo visa kaktą?

Buna nuo juo beria. Kazkiek gali palaukti, gali ikalti tavegilo, bet jei nepraeis tai reiks nutraukti.

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metanis
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#292 2020-05-03 22:59

Re: DNP Pradžiamokslis

Is praktikos arba is literaturos kiek gali pakilti kuno temperatura nevirsijant 400mg?

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Bune
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#293 2020-05-03 23:07

Re: DNP Pradžiamokslis

metanis rašė:

Is praktikos arba is literaturos kiek gali pakilti kuno temperatura nevirsijant 400mg?

38.5 is praktikos prie 600mg
Prie 400 nesimatavau kazkaip nera jau taip blogai galima gyventi.
Literatura raso 2 3 bet cia visur skirtingai jau 3 manau prie 1g nejuokauciau as su juo.

Paskutinį kartą taisė Bune (2020-05-04 00:05)

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metanis
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#294 2020-05-04 09:12

Re: DNP Pradžiamokslis

Bune rašė:

metanis rašė:

Is praktikos arba is literaturos kiek gali pakilti kuno temperatura nevirsijant 400mg?

38.5 is praktikos prie 600mg
Prie 400 nesimatavau kazkaip nera jau taip blogai galima gyventi.
Literatura raso 2 3 bet cia visur skirtingai jau 3 manau prie 1g nejuokauciau as su juo.

aciu.

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bender
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#295 2020-05-17 12:56

Re: DNP Pradžiamokslis

Here’s the DNP manual written by Aiml at hecial Aarcy…

The DNP manual!

(updated sections and additions are in bold)

Why you might want to use DNP.

Add some DNP to an animals diet. DNP can get metabolism up at least 50% which is conservative as some say 75% This would mean if the animal eats 3000 calories maintenance they are now at 1500 calories a day with no change in diet! A 2500 calorie a day would leave them with 1250 calories a day. There are 4086 calories in 1lb of fat and at 3000 calories a day your DNP adjusted calories for the day is 1500. Multiply that x 7 days to give you 10500 calorie deficit which is 2.5 lbs of fat loss for the week. At the 2500 calorie you have a 2.14 lb fat loss. These are both below what the BO diets claim and you don’t have to stop eating!

If your animals weigh around 200lbs their effective dose is 400mg and the max can be as high as 800mg a day, however, with the discovery of how ALC works and from research on DNP from back in the 20’s and 30’s along with the availability of anti-oxidants specific for mitochondria, as well as it is more tolerable and easier for the body to cope with the free radical production if a low dose routine in the order 100-200mg a day is used for a longer period of time and in fact, like the usage of ALC which also excites mitochondria and produces free radicals AND IMPROVES performance, this low dose regimen is likely to IMPROVE performance, too.

High fat diets market on the basis that you are going to be able to lose 1.5-2lbs of fat by just changing your diet! WRONG and physiologically Impossible.

1 gram of fat is 9 calories. There are 454 grams in a 1 pound. This gives you 4086 calories for 1lb of fat. If you want to lose that 1lb of fat you have to have a 4086 calorie deficit to do it. In other words, you need -4086 calories in your diet if you want to lose 1 lb of fat. Now, Let’s say you are at 3000 cal a day for maintenance. That is 21000 calories a week. You believe the marketing of the post above and think you can lose 1.5lbs of fat. That, my friends, is 6129 calories which you have to subtract from 21000 which leaves you with 14871 calories for the week or 2124 calories a day. You are going from 3000 to 2124 a day. If you want to lose that great sounding 2 pounds you are now at 12828 for the week or 1832 calories a day.

Let’s be realistic and put you at 2500 maintenance calories. To lose 1.5lb you now need 11371 calories a week or 1624 calories a day or a nearly 900 calorie a day change. To lose the magical 2lb a week you need 9328 calories for the week or 1333 calories a day or a 1167 calorie change per day! That is rather difficult, but let?s add some DNP which can get you metabolism up at least 50% which would mean you are now at only 1500 calories a day for a 3000 calorie diet with no change in diet! A 2500 calorie a day would leave you with 1250 calories a day.
These are both below what the ketogenic and high fat diets claim and you don’t have to stop eating!

Keep in mind that everyone is different.

Don?t take DNP on an empty stomach or it will feel like you have indigestion for most of the day.

I wanted to stress not to just go balls out (5mg/kg) and you should move up gradually on DNP for your first experience.

If you have an allergic reaction with red spots and itching then stop the DNP and get some Benadryl and then you should be able to start again.

The type of diet will also affect how you feel, as well as the type of workouts you are doing. These are variables you also will have to figure out for yourself.

The logic of my dieting regimen follows that while you are on DNP all the glycogen/glucose is being scavenged to provide ATP for the mitochondria so you will want to eat a NORMAL diet. High fat ketogenic diets are not going to help you build muscle even though DNP is anti-proteolytic (protein sparing)… Furthermore, when you eat fat it is more likely to go to fat! That is scientifically proven. So if I’m trying to burn fat, why would I want to eat it right back?

DNP is anti-proteolytic which means it uses carbohydrates or fats exclusively to supply energy for the mitochondria and does not facilitate muscle breakdown, however, this does not therefore mean DNP is positive for muscle building. The cells are running in overdrive and they are not going to be looking to make themselves bigger which requires even more energy, with this primarily being the case with high dose DNP as low dose could be different

Everyone is different and other supplements you take will affect your results, but as a whole, most people are not going to do well or feel well on high fat and high or low dose DNP. I also have found that taking particular supplements helps with how will you feel while on the DNP.

I feel better when I don’t do huge carbs, however, when I don’t do any as in high fat type diets, my workouts suffer just the same. Each individual has to decide for themselves and put those factors into perspective with what their goals are and how fast they want to accomplish them and how bad they are willing to feel for the desired weight loss.

Additionally, high fat diets or even low carb/high protein diets REDUCE insulin which is a key to maintaining leptin levels during dieting as it’s been found that AFTER a diet has gone for about 2 weeks the leptin sets lower primarily due to the body not seeing as much insulin as it is used to. And if that’s not bad enough, at the END of the diet even when the food intake returned to normal, LEPTIN DID NOT meaning that when the diet was over the dieters body stored fat FASTER which is why diets don’t work for many…therefore, eat a normal diet and get insulin up once a day or more so the body doesn’t think it is starving and lowers leptin.

WARNING: DNP will turn everything and anything yellow including skin, clothes, carpet, and hair. I dropped a capsule in my DNP container and bent over to look for it and my hair touched the edge of the container and my hair got dyed yellow! My hair did not even touch the DNP, but just the side of the container for about 2 seconds! DNP for the most part is not removable or bleachable with normal chemicals. It will also track. By that I mean, you think you have washed it off your hands and you touch something and later you see yellow spots on what you touched. If you are making caps you need 2 pairs of gloves, at least, as the DNP goes through the first pair due to an atrraction it has for moisture. DNP sublimes and floats. Due to this sublimation it will land on EVERYTHING if you leave it out even if there is no air circulation. DNP goes through EVERYTHING including plastic, hdpe plastic, pet plastic, plastic bags, nitrile and latex gloves. It can be washed out of clothing with hot water and detergents that have phenolic compounds in them such as Tide. DNP is not solvated by laquer thinner, acetone, paint thinner, or turpentine or any of the common organic solvents. If you wash your hands immediately after touching DNP with gamma-butyrolactone, otherwise know as GBL and used to make GHB, and then a detergent such as Dawn dishwashing soap, the stain will come out for the most part.

Using taurine as a filler GREATLY lowers the tracking and transfer of DNP and totally eliminates it leaching through plastic bags. Another better hand cleaner is oxybrite.

I have to say that a certain guru which some people keep quoting is what WAS PROVEN to be a very unreliable source. I will give him credit for bringing DNP to the forefront, but I will bet you a million bucks that he has never used it or mixed it. Here is a quote that bears this out; 'I don’t see what the worry is about everything turning yellow? I have no problems, I just dry it out and cut it with a credit card and cap it.?

That is total BULLSHIT!. Anyone who has used or mixed DNP powder knows that it will get on EVERYTHING and turn it yellow. It goes through plastic bags. Just today I was sending someone 3g for research and I put it into a ziploc and 2 hours later I came back and the envelope under the bag was YELLOW! It goes through 1 laver of rubber gloves. It turns white HDPE bottles yellow. It floats everywhere. I had to put my stuff in a hood because it got on everything I had sitting out and I had to wash all my glassware and scales before I could use them again. DNP floats by sublimation which would be known just be reading the safety sheet or the Merck Index…

On the basis of that statement alone I have some real problems believing anything he says on the subject, but another famouns quote is, ?DNP will raise your body temp high enough to kill you!? This also proves that he has never done it because as you will find, your body temp only goes up about one degree. Ok, enough about the fake guru.

Someone just asked me if the utiutiu I sent them was real. Well, if you want a test then rub it on your hands and throw some on your carpet. When your carpet has to be replaced because NOTHING can remove the yellow and you look like a total ass because your hands are bright yellow, then you can ask me if it is real!

Mostly people are taking DNP for 1 week at a time because it exhausts you and you sweat a lot, usually that is what I do, but due to my ?work? with DNP I got a dose while on an ECA week and that combination of DNP-ECA was like methamphetamine. If you are having problems with lethargy I would now recommend theophylline or Stim #2 or Analog-S or nicotine gum which is another stim

In fact the DNP with stimulant regimen was better because it had less side affects. I would venture that DNP-PPACA would also have the same methamphetamine type effects. At this time I do not know, however, whether PPA works on the same receptor so I would not do them back to back in cycles. ECAY where Y is yohimbine is also a combination that has meth type benefits. Clen-DNP did not exert any magical meth benefits that I noticed. Have not taken PPACA or PPACA-DNP or PPACAY.

Tyramine and yohimbine are awesome and someone was getting goosebumps and asked a pharmacologist what the goosebumps were about. The pharmacologist told him that it meant he was burning a lot of calories. I love this combination and it is just like meth due to large releases of NA although it only lasts 4 hours or so.

DNP also ?upgrades? the effects of clen. If you have used clen before and it had/has stopped working, then DNP will bring back it?s glory. I would surmise now that the mechanism of how this works is more an indicator of how DNP does NOT work in that DNP DOES NOT get to the mitochondria via beta receptors. When the beta receptors are used with such chems as CLEN, ephedrine, t3, etc, the cell senses homeostasis is changing and in order to slow things down, the cell then produces MORE ALPHA receptors which simply outcompete the betas by sheer numbers and when they grab a chemical such as clen, they render it useless. (Yohimbine or alpha yohimbine being alpha antagonists can subvert this mechanism far better than the bunk busted chems like ketotifen.)

This phenomenon of how DNP upgrades clen further lends credence to the fact that when DNP is used, the changing homeostasis of the cell does NOT invoke alpha receptor upgrade.

I like to keep the clen and DNP a week apart due to the affects they have on T3 although they work on different mechanism it is just a precaution to keep from shutting down the T3. You could add Yohimbine or alpha-yohimbine to it for an added benefit which will not cause downgrade of anything. Reports on DNP-Y indicate a higher rise in body temperature on this combination.

And if we think for a moment of how DNP stops the conversion of T4 to T3 either via heat affecting the enzyme or directly on the enzyme itself which really matters not because the point is that systemic T3 is REDUCED when DNP is used. This is not all bad because when the body doesn’t see T3 it then ups TSH and T4 and when DNP is stopped you have a high level of T4 available to be converted to T3.

Due to the systemic affects of DNP, it affects EVERY cell in the body that has mitochondria, including smooth (digestive) and muscle and fat as well, you will not see a significant rise in body temp like you see with clen or ECA. Clen and ECA work primarily on muscle cells and that causes a rise in body temp just as if you were working out. I don?t know why this is such a difficult concept for some to understand, but I was sweating like hell recently, and I took my temp and it was 95.8. ON DNP!

DNP MECHANISMS

The basics first. DNP is a classified as a chemical poison. It?s mode of action is to disrupt the ETC (electron transport chain) and cause uninhibited exchange of protons. This exchange of protons is what is responsible for making ADP into ATP. NOTHING can stop the disruption of this process once it starts. DNP works no matter what! High or low T3 has nothing to do with whether or not DNP affects the mitochondria and burns off extra energy. DNP gets into the cell and into the mitochondria and causes proton release. No other hormones are needed or noted.

Even so, it works in much the same way as clen or ECA or PPACA or thyroid. They ALL cause the metabolism to speed up. These all work via the mitochondria as well, although the non-DNP diet drugs work on the receptors first and DNP goes directly to the mitochondria, the results are the same which is speeding up the metabolism to burn fat.

Some other important facts you should know are how ephedrine and beta-3 activation drugs work.
These both cause uncoupling of the ETC chain just like DNP! Ephedrine works part of its magic via beta-3’s and much research has been done looking for a magic beta-3 drug. Why, we have it and it is called DNP! If you are sitting around and something is making you hotter, you are most likely experiencing an uncoupling of the ETC chain. No big deal, but DNP just causes a greater effect.

I knew there was a reason that you CANNOT die from DNP usage, at least the doses many are doing. I talked to a couple people about this but just couldn’t find the info to prove it. Ok, so what does DNP do? It uncouples the ETC or oxidative phosphorylation as was elaborate upon above, allowing electron flow to go unchecked at maximal rate and resulting in heat production and ATP depletion.

ATP depletion is the key. What condition exists when you have totally exhausted all ATP and no more is being created? A very good instance we all know about is when you are dead and it is called ?rigor mortis?. Rigor mortis results because no more ATP is binding to the myosin head of the sarcomere in the muscle fibers.

So what does this have to do with us? No one has ever had rigor mortis on DNP or even severe cramping that has ever been documented. Furthermore, and to be more specific as to the uncoupler DNP, the electron gradient is collapsed and it runs unchecked at maximal as I have explained above, but as the gradient continues to increase electron transport becomes more difficult and the process SLOWS! Additionally, under very large artificially created electrochemical proton gradients, normal electron flow stops and may even result in
REVERSE electron transport flow!

All that was complicated and here is what it means. The respiration chain in the mitochondria which controls energy release has a safety mechanism which allows for feedback controls to keep you from killing yourself. This is also another reason you will not want to do DNP for long periods. If you have taken enough as to create a large gradient the flow of electrons your burning of calories might even STOP! This will happen if you don?t eat enough calories and appears to be more detrimental on a high fat type diet because as you will see below, glucose can ameliorate charge differentials in the mitochondria and at the cell surface while on DNP.

DNP works NO MATTER WHAT! It uncouples the electron transport train (ETC) and there is nothing you can do to stop it. Some have said it doesn’t work after a small dose or only after taking DNP for 2 days or so. I think they are the same kind of person who would take a drink of beer and say, ‘Oh, I’m not drunk so alcohol doesn’t work’! Alcohol still affects your brain cells and hormone levels and slows down the metabolism. Just because you didn’t drink enough to be drunk doesn’t mean nothing happens!

As mentioned above, DNP is anti-proteolytic. This means DNP does not break down protein via the mechanism through which DNP works. DNP is actually better for you than cardio because exercise is PROTEOLYTIC which in itself is another reason to not be doing a high fat diet. High fat diets and exercise both lower insulin and raise glucagon levels which cause breakdown of protein. It is a proven fact that 10-20% of energy from exercise comes from AA breakdown as well as release of glutamine from the cells. This is why you might want to actually adopt a higher protein diet and/or supplement in some alanine

DNP burns calories and does not affect hormone levels. Someone said something about it causing ketosis which is likely if you don’t eat any carbs, but DNP is not by itself going to affect insulin levels like glucose disposal agents metformin or phenformin or the bunk busted chems ALA or rALA

DNP is not going to be advantageous to muscle building. THIS DOES NOT DISAGREE WITH WHAT I WROTE ABOVE! It is anti-proteolytic via its mode of action, BUT if there is not enough energy in the cells to build muscle it ain’t gonna happen. Again, diet is key. More than that we can look to a newer chemical called acetyl-L-carnitine which everyone surely knows about and the mechanism of ALC is EXACTLY the same as DNP in that it is also a stimulator of the mitochondria so much so in fact that in early tests of ALC, if the proper antioxidants weren’t taken, the free radical release caused by ALC would be detrimental to the cell and the animal as a whole. Since ALC is good for nerve excitation and working out, low dose DNP which is working by nearly the exact same mechanism can ALSO be beneficial to workouts.

DNP is one of the SAFEST drugs you can take!!! WhAT? Am I nuts?! I am basing this on DNP’s mode of action. DNP has one purpose and mechanism and affects nothing else, but the mitochondria. DNP does not affect hormone levels as do clen, ECA, T3, etc. It has no side affects that you don’t expect such as shakes or cramping. Compare DNP to some of the Drugs the FDA has approved and look at their side effects and then tell me what is safer! HAHA!

After you read this study you need to ask yourself, ‘need I say more?’ In the earlier paragraph on the mechanisms of DNP on the mitochondria I explained the safety mechanism which could keep DNP from being totally depleted of ATP. Some were saying ATP depletion would result in cell death. The study below illustrates another mechanism which I didn?t know about. The crux of it can be summarized by this sentence: 9The following is bold because to this day people still believe the bunk that ATP is depleted) ?The failure to find a reduction in ATP concentration in either fibre type during prolonged exercise in the face of a progressive increase in the number of fibers showing little or no glycogen concentration suggests that protective mechanisms exist that prevent an energy crisis. The nature of these protective mechanisms remains to be elucidated. ? In other words,

When glycogen is gone there is a mechanism which keeps ATP from being depleted which is unknown at present!

Energy metabolism in human slow and fast twitch fibers during prolonged cycle exercise.

Author Ball-Burnett M; Green HJ; Houston ME
Address Department of Kinesiology, University of Waterloo, Ontario, Canada.
Source J Physiol (Lond), 437():257-67 1991 Jun
Abstract

The effects of prolonged exercise on energy metabolism in type I and type II muscle fibers in the vastus lateralis muscle were investigated in six male subjects (20.0 +/- 0.5 years, mean +/- S.E.M.) who performed one-legged cycling at 61% of maximum O2 consumption (VO2,max; determined with one leg) until fatigue or for a maximum of 2 h. 2. Analysis of pools of freeze-dried fibers obtained by needle biopsy and separated into specific types by the myofibrillar ATPase histochemical procedure indicated higher (P less than 0.05) lactate concentrations in type II fibers compared to type I fibers at 15 min (43.9 +/- 9.7 and 51.2 +/- 9.8 mmol (kg dry wt)-1) and at 60 min (18.2 +/- 4.7 and 25.9 +/- 6.5 mmol (kg dry wt)-1). No differences existed in lactate concentration between fibre types for pre-exercise (10.0 +/- 1.6 and 13.3 +/- 2.8 mmol (kg dry wt)-1) or post-exercise. 3. Glycogen degradation was most pronounced in type I fibers. By the end of exercise, glycogen concentration was 82.4 +/- 45 mmol glucosyl units (kg dry wt)-1 in type I fibers and 175 +/- 62 mmol glucosyl units (kg dry wt)-1 in type II fibers. 4. No significant changes in ATP and creatine phosphate (CrP) were found in either fibre type with exercise. 5. It is concluded that, at least for lactate and glycogen, fibre-specific differences are evident in prolonged submaximal exercise. The cause of the difference probably relates both to the unique energy metabolic characteristics of each fibre type and to the manner in which they are utilized during the exercise. 6. The failure to find a reduction in ATP concentration in either fibre type during prolonged exercise in the face of a progressive increase in the number of fibers showing little or no glycogen concentration suggests that protective mechanisms exist that prevent an energy crisis. The nature of these protective mechanisms remains to be elucidated.
DNP will make you breathe harder via a mechanism called cellular hypermetabolism. This also happens when you take ALC and if you take to much of it you will notice that you are breathing HARDER during a workout, but not doing any better. You aren?t going to die if you are breathing hard! DNP works by increasing ventilation and oxygen consumption via hypermetabolism of the cell. DNP makes you breath hard.

Role of tissue hypermetabolism in stimulation of ventilation by dinitrophenol.
Author Levine S
Source J Appl Physiol, 43(1):72-4 1977 Jul
Abstract

Several authors have hypothesized that tissue hypermetabolism accounts for increases in ventilation (VE) elicited by 2,4-dinitrophenol. However, some data in the literature indicate that stimulation of VE by isomers of dinitrophenol is unrelated to tissue metabolic rate. To test this latter concept, we compared three different isomers of dinitrophenol (i.e., 2,4-dinitrophenol (2,4-DNP), 2,5-dinitrophenol (2,5,-DNP), 2,6-dinitrophenol (2,6-DNP) with respect to stimulation of VE and with respect to stimulation of oxygen consumption (VO2). In all experiments, 3-4 mg/kg of one dinitrophenol isomer was administered to chloralose anesthetized dogs by intra-arterial infusion. 2,4-DNP elicited large increments in both VE and VO2, 2,6-DNP elicited moderate increments in both VE and VO2, whereas 2,5-DNP elicited small increments in both VE and VO2. These observations demonstrate a correlation between ventilatory and metabolic changes affected by isomers of dinitrophenol. Accordingly, these results are consistent with the hypothesis that ventilatory stimulation by congeners of dinitrophenol is related to tissue hypermetabolism.

The safety of DNP:
desolation wrote:
Not sure if anyone has seen these before but I thought I would post them as they provide evidence for possible DNP health benefits.

Novel neuroprotective, neuritogenic and anti-amyloidogenic properties of 2,4-dinitrophenol: the gentle face of Janus.

De Felice FG,
Ferreira ST.
Instituto de Bioquimica Medica, Programa de Bioquimica e Biofisica Celular, Universidade Federal do Rio de Janeiro, Brazil. felice@bioqmed.ufrj.br

In Roman mythology, Janus was the god of gates, doors, beginnings and endings. He was usually depicted with two faces looking in opposite directions. Janus was frequently used to symbolize change and transitions, such as the progression from past to future or from one viewpoint to another. 2,4-dinitrophenol (DNP) and other nitrophenols have long been known to be toxic at high concentrations (the ‘bad’ face of DNP), an effect that appears essentially related to interference with cellular energy metabolism due to uncoupling of mitochondrial oxidative phosphorylation. Five years ago, however, we published the first report showing that low concentrations of DNP protect neurons against the toxicity of the amyloid-beta peptide (De Felice et al. (2001) FASEB J. 15:1297 - 1299]. Since then, other studies have provided evidence of beneficial actions of DNP (at low concentrations), including neuroprotection against different types of insult, blockade of amyloid aggregation, stimulation of neurite outgrowth and neuronal differentiation, and even extension of lifespan in certain organisms. Some of these effects appear to be due to mild mitochondrial uncoupling and prevention of cellular oxidative stress, whereas other actions are related to activation of additional intracellular signaling pathways. Thus, a novel and ‘gentle’ face of DNP is emerging from such studies. In this review, we discuss both toxic and beneficial actions of DNP. The evidence available so far suggests that DNP and other compounds with similar biological activities may be of significant interest to the development of novel therapeutic approaches for neurodegenerative diseases and other neurological disorders.

The mitochondrial uncoupler 2,4-dinitrophenol attenuates tissue damage and improves mitochondrial homeostasis following transient focal cerebral ischemia.

Korde AS, Pettigrew LC, Craddock SD, Maragos WF.

Department of Neurology, University of Kentucky, Lexington, Kentucky 40536-0284, USA.

Ischemic stroke is caused by acute neuronal degeneration provoked by interruption of cerebral blood flow. Although the mechanisms contributing to ischemic neuronal degeneration are myriad, mitochondrial dysfunction is now recognized as a pivotal event that can lead to either necrotic or apoptotic neuronal death. Lack of suitable ‘upstream’ targets to prevent loss of mitochondrial homeostasis has, so far, restricted the development of mechanistically based interventions to promote neuronal survival. Here, we show that the uncoupling agent 2,4 dinitrophenol (DNP) reduces infarct volume approximately 40% in a model of focal ischemia-reperfusion injury in the rat brain. The mechanism of protection involves an early decrease in mitochondrial reactive oxygen species formation and calcium uptake leading to improved mitochondrial function and a reduction in the release of cytochrome c into the cytoplasm. The observed effects of DNP were not associated with enhanced cerebral perfusion. These findings indicate that compounds with uncoupling properties may confer neuroprotection through a mechanism involving stabilization of mitochondrial function.

The mitochondrial uncoupling agent 2,4-dinitrophenol improves mitochondrial function, attenuates oxidative damage, and increases white matter sparing in the contused spinal cord.

Jin Y,
McEwen ML,
Nottingham SA,
Maragos WF,
Dragicevic NB,
Sullivan PG,
Springer JE.
Department of Anatomy and Neurobiology, University of Kentucky Medical Center, Cardinal Hill Rehabilitation Hospital, Lexington, Kentucky 40536, USA.

The purpose of this study was to investigate the potential neuroprotective efficacy of the mitochondrial uncoupler 2,4-dinitrophenol (DNP) in rats following a mild to moderate spinal cord contusion injury. Animals received intraperitoneal injections of vehicle (DMSO) or 5 mg/mL of DNP prior to injury. Twenty-four hours following surgery, mitochondrial function was assessed in mitochondria isolated from spinal cord synaptosomes. In addition, synaptosomes were used to measure indicators of reactive oxygen species formation, lipid peroxidation, and protein oxidation. Relative to vehicle-treated animals, pretreatment with DNP maintained mitochondrial bioenergetics and significantly decreased reactive oxygen species levels, lipid peroxidation, and protein carbonyl content following spinal cord injury. Furthermore, pretreatment with DNP significantly increased the amount of remaining white matter at the injury epicenter 6 weeks after injury. These results indicate that treatment with mitochondrial uncoupling agents may provide a novel approach for the treatment of secondary injury following spinal cord contusion.

DNP actually reduces free radicals.
desolation wrote:
Free radicals are actually reduced in the mitocohondria by DNP.

Prevention of Mitochondrial Oxidative Damage as a Therapeutic Strategy in Diabetes
Katherine Green, Martin D. Brand, and Michael P. Murphy

As an elevated µH+ (proton electrochemical potential gradient) favors superoxide production, limiting the magnitude of this gradient under state 4 conditions should decrease superoxide production (2 . Artificial uncouplers such as 2,4-dinitrophenol (DNP) make the inner membrane permeable to protons, thereby lowering the µH+ (proton electrochemical potential gradient), which accelerates respiration and consequently oxidizes the electron carrier pools (28,29). Uncouplers are typically lipophilic weak acids for which both the protonated and unprotonated forms are lipid soluble, thus enabling them to catalyze proton movement through the phospholipid bilayer by lowering the activation energy for proton leak. Even low concentrations of artificial uncouplers have been shown to lower the rate of superoxide production by mitochondria.

Diabetes – 1 Feb 04

Prevention of Mitochondrial Oxidative Damage as a Therapeutic Strategy in...

Hyperglycemia causes many of the pathological consequences of both type 1 and type 2 diabetes. Much of this damage is suggested to be a consequence of elevated production of reactive oxygen species by the mitochondrial respiratory chain during...
How to feel good on 600mg of DNP!

This is not an advertisement because I No longer sell encapsulated DNP for research than I care to spend time making. Note: I don’t sell it.

The longer I took DNP the more I realized those who had originally recommended DNP use were not looking at the big picture, and they had most likely never used it or mixed it themselves, and/or were just complete morons!

Myth #1.
You die on DNP from heat related to overdose.
Wrong!
You die from dehydration resulting in heat exhaustion and then heat stroke. Fact is that DNP actually LOWERS your body temp.

Myth #2.
You can do it on high fat-low carbohydrate type diets.
NO YOU CAN?T!
High fat-low carbohydrate diets are based on keeping your blood sugar and insulin low. DNP will also drive down your blood sugar, so if you want to have blurry vision due to low blood sugar and feel like hell, you go right ahead. Glucose also has some beneficial cellular effects when used with DNP… Which is in a study below.

Myth #3. You will go blind.
Right! If you do high fat-low carbohydrate diets and don?t keep your blood sugar up and/or don?t take pyruvate and the right anti-oxidants. The reason people had trouble with cataracts in the 20’s and 30’s is because they DID not understand the need for anti-oxidants which can prevent this and other problems from free radicals produced not only from DNP, but from plain old every day living.

Myth #4.
You can?t work out on DNP.
Yes you can, if you know what you are doing and which I am about to tell you.

As you may already know you, should be taking the following per day.

1200-1500mg magnesium in 2-3 divided doses.
1000mg vitamin C.
1200IU of vitamin E
200mcg of selenium.
1000-2000mg of calcium (can?t take it with the magnesium, though. Take it before bed)
Melatonin if you can?t sleep and it is also one of the best and cheapest anti-oxidants.
50mg of zinc a day
one iron tab as hemoglobin is a protein as well.
Taurine at 6-12g a day.
A folic acid tab.

I think taurine will be most beneficial for cramping and holding onto water. I have worked with some mountain bikers that were having trouble with cramps and had tried using the proverbial potassium supplementation cure and it didn?t work. I had them take the taurine and magnesium and the cramping went away. Taurine is also give to people who have leg cramps at night at a dosage of 3-6g a day resulting in total alleviation of the cramps. Clenbuterol depletes the liver of its taurine supply which changes the osmotic pressure and therefore stops T4-T3 conversion. Taking supplemental taurine can alleviate this.

Glutamine also regulates water, but is a bitch to take and unless you want your small intestine to absorb most of it you have to take it sublingual. You can fool the body a bit by putting it into your carb/protein drink after you work out or by taking 2g doses throughout the day. Glutamine ALSO causes a rise in insulin.

IF you are on clenbuterol, pyruvate and glycerol will help you a little, and I don’t know why, but I still got some cramping on clen after an event even on P and G. The latest research I have indicates that the reason clen may cause cramping is due to TAURINE depletion so by taking the 3g a day taurine you should be able to ameliorate those effects as well and keep your thyroid levels normal as well.

In addition to the vitamins and minerals you should be taking:

3-6g Pyruvate §
3 tablespoons Glycerol (G)

If you can’t get the G and P go right to the taurine which may be cheaper as well.
Glycerin (glycerol) is avail in the skin care section of your pharmacy and 4oz is about1-2 dollars or there are larger versions in white bottles and the brand name is H something. Just buy it from a vet and a gallon is around $20!

I felt like utiutiu when I went above 400mg and sweat profusely on single large doses of 600mg and 800mg which lasted for 2 days. I weigh around 95kg (210).

The object of the DNP dosing with the glycerol and pyruvate was to test their benefits on what is considered an overdose of DNP while maintaining my exercise level in the middle of summer.

Here is what I was taking:
600mg of DNP which would be 6mg/kg which is well above the recommended 3-5mg.

DNP is said to have a half life of 36 hours and this is what I have based the following dosing scheme. I also have anecdotal evidence that DNP can last 48 hours or more. When I took an 800mg dose after 3 days on 300mg a day I sweat for 48 hours straight and that 800mg was the last dose I took.

You have to divide the 600mg into two doses of 300mg 12 hours apart.
After you hit your 600mg limit you don?t take the next 300mg for 36 HOURS from the first dose!
So, if I took the first dose at 6AM on Sunday morning and the second 300 mg dose at 6PM Sunday night, the 3rd dose would not be until 6PM on Monday evening. The fourth dose would again follow 12 hours from the 3rd which would be at 6AM on Tuesday morning.

I am also taking EC with this just for fun although at only 2 x a day for the EC to keep energy levels up and lessen the carb craving that goes with DNP.

How am I not sweating all over the place and not feeling like utiutiu and/or dehydrating in the middle of summer while going on hour or longer rides in 85 plus heat?. Let me tell you again that I hated the way DNP made me feel.

YOU HAVE TO TAKE GLYCEROL AND PYRUVATE!
I don?t know if you can take one without the other because I was using the glycerol (G) and pyruvate § to enhance endurance and stem dehydration which I am very prone to. I think, however, that you will have to do them both as there may be a synergistic benefit. I have taken G alone and while you have more water to hold on to, you just seem to sweat more which is also backed up by the research. The G-P cocktail let me drink ½ my normal volume of water on rides and that is what made me try the DNP-ECA experiment.

Glycerol dose. YOU ONLY NEED 1 TABLESPOON 3 TIMES A DAY! One in the morning, one in the afternoon and one right before bed. Don?t listen to the researchers who tell you to take 1 gram for every kg body weight 1-2 hours before and event. They are idiots and obviously have never taken it or asked the athletes how they feel. Let me tell you, you feel awful taking that much glycerol! You feel bloated and sometimes get a headache and you piss A LOT! 1 tablespoon 3 times a day comes out to ½ what they recommend to take 2 hours before an event. The glycerol keeps your muscles hydrated and limits the sweating. It will fight the dehydrating effects of the ECA. As we know, DNP is carbohydrate/fat specific and glycerol also is a 3 carbon carbohydrate source that can?t go to fat!. Glycerol also increases power output which may be an added benefit of the type of carb source it is. Glycerol is converted to glucose in the liver and in the liver is where it stays for the most part and does not, therefore, raise insulin levels.

Before I explain the pyruvate, let me tell you that glycerol and glycerin are the same thing! A good recipe for taking your glycerol is 1 packet of Kool-aid, 1/8 cup sugar, 1 tablespoon glycerol and 32-oz of water. The glycerol makes the kool-aid taste like OJ because there are alcohols and fermentation products in the OJ which the glycerol mimics.

Pyruvate dose. 2-5grams a day. Start out at 900mg or so 3 times a day and go up from there. I am at 1.5g 2-3 times a day and if you don?t work your way up it will give you gas and the runs. As I mentioned above, I think the P is working synergistically to hold on to the water in your muscles. Additionally, it is another 3 carbon energy source and/or it is manipulating the Krebs Cycle intermediates and allows for a different energy production pathway. Pyruvate changes/manipulates an ATP/energy pathway and decreases lactic acid output and if it ain?t the Krebs cycle I don?t really care. It works.

Some abstracts on the benefits of pyruvate.

Pyruvate and the heart and glucose and insulin.

Cardiac metabolism and electromechanics of human heart.
Author Prasad K
Source Recent Adv Stud Cardiac Struct Metab, 10():119-37 1975
Abstract

The effects of substrates on the metabolic inhibitor-induced changes in the action potential and contraction of papillary muscles obtained from patients undergoing corrective open-heart surgery were studied. Anoxia produced a marked shortening of the action potential duration and a decrease in the resting potential, rate of rise of action potential, effective refractory period, and contractility. In anoxic muscle, although glucose completely restored the action potential duration, effective refractory period, and resting potential to control levels, it was unable to completely restore the contractility to the control level. Substrate depletion and metabolic inhibitors (iodoacetate, dinitrophenol) produced effects similar to that of anoxia, but at a faster rate. Glucose restored the action potential and, to a lesser extent, contractility to the control level in dinitrophenol-treated muscle but was ineffective in so doing the iodoacetate-treated muscle. Pyruvate, however, was effective in restoring the action potential and contracility in iodoacetate-treated muscle. Pretreatment of the muscle with glucose and, particularly, with glucose plus insulin prevented the combined effects of anoxia and lack of glucose on the action potential and contractility for a prolonged period. These results suggest that intravenous infusion of glucose and insulin before and during surgery might prevent or reduced the effect of anoxia on the electrical and mechanical activity of the heart during open-heart surgery.

Pyruvate was able to restore the action potential (charge) of cells treated with DNP! Unfortunately, most of you won?t understand what an AP is even if I explained it, but I will tell you that restoring it is signiificant!

Now you have a recipe on how to feel good on an overdose of DNP! To recap you need:
3 Tablespoons glycerol 3x a day.
1g Pyruvate 3x a day.
Taurine at 3g a day.
DNP at 36 hour intervals.

If you start to feel bad, just drink some sugared pop or take some glucose or maltodextrin with your psuedo-OJ mix. The only drawback is that you will still smell rather bad and will emit a vinegar type odor although you won?t be sweating all over everything. If you notice you are starting to sweat more it is time for another glycerol dose.

Use of AS during DNP

You can use DNP during an AS cycle although the muscle loss from DNP is minimal, if any, so I don?t think this is the best use of your AS. If, however, you have hit a plateau the DNP for a week will help you break through that plateau in the subsequent week off. Now, I have experienced this, as have others, but as to whether or not it is from an upregulation or having a rush of T3 available or a type of overcompensation rebound is unknown, but it is cool and it happens…

Use of AS after DNP or dieting.

DNP and dieting BOTH stop conversion of T3-T4. T3 is responsible for protein synthesis. If you have been on a diet for 2 weeks or more your thyroid will be depressed and so will protein synthesis due to low T3. By adding AS you will be increasing protein synthesis while waiting for your thyroid to come back online so you won?t get fat right after a diet.

Use non-aromatizing AS like equipoise, ganabol, maxigan, trenbolone (finaplix or Anibolan), winny-V. Or you can use testosterone and an anti-aromatase like cytadren or arimidex. If you want to keep the fat off you HAVE TO use those anti-aromatazes with the testosterones and d-bols as they are the only ones that stop conversion of testosterone to estradiol. Estradiol conversion will make you fat, especially around the waist! If you have to use a testosterone and want to lose fat, I would use cytadren because it increase hormones which cause fat loss as well as increasing IGF-1 levels! (Bet you didn?t know that!) I would, however, not stay on cytadren longer than one month and dosage is one tab divided into 4 doses per day.
A line from a study showing that estrogen makes you fatter for the non-believers!
Obes Res 1995 Nov;3 Suppl 4:561S-568S
Topical fat reduction.
Greenway FL, Bray GA, Heber D
Department of Medicine, UCLA School of Medicine, Torrance, CA, USA.

The fat on women’s thighs is more difficult to mobilize due to increased alpha-2 adrenergic receptor activity induced by estrogen. Lipolysis can be initiated through adipocyte receptor stimulation (beta adrenergic) or inhibition (adenosine or alpha-2 adrenergic) or by inhibition of
phosphodiesterase.

While yes, they talk about women and estrogen and fat, the mechanism is still absolute and spans the sexes. Estrogen makes fat cells resistant to lipolysis. Still want to take that test without and anti-estrogen?

Get to fat burning faster!

This is something you can try after you have used DNP once and know your tolerance and is a DNP manual exclusive! Your working dose will be around 400mg a day, correct? The first day, however, you are going to take 600mgs in divided doses! It takes DNP a couple days to build up so this won’t bother you in the least. On the second day you will start taking 200mg caps every 8 hours until you are sweating or getting the heat you want. Now you are at your tolerance dose and you can space it out to the 36 hour dosing.

NEW!
Use a blood buffer to combat free radicals and lactic acid!

Add up to one tablespoon of baking soda, sodium citrate, or potassium citrate to your drink of choice throughout the day. A mix of the sodium and potassium would be best. Why?
What does DNP and exercise have in common? During high intensity exercise (supramaximal) ATP production is supplied by anaerobic glycolysis. This increases levels of H+ (protons) both inside and outside the cell via lactate and results in the feeling of fatique (Hermansen and Osnes; Sahlin) In the past, the use of sodium bicarbonate (baking soda) has been used and has been shown to decrease acidosis via buffering of the blood. The problem with baking soda is gastric distress and high salt intake with the recommended dosage of 300mg/kg which is around a tablespoon of baking soda for most people. Dosage for sodium citrate is 100mg-500mg per kg and did not give stomach problems to the users. Time to exhaustion was increased 15% which is the same as with baking soda. Alkalosis (making the blood basic) has been found to increase the rate of lactate and proton release from muscle into the blood. An increase in muscle pH causes phosphofructokinase inhibition (PFK) which is the controlling enzyme in glycogen utilization and therefore causes an increase in lactate formation. Those two mechanisms also will hold true for DNP as DNP releases protons which causes the heat. Get it out of the cell with the citrates.

Testomonial:
Hey animal just thought I?d let you know the great results I had with the DNP. I got tested hydrostatically and I’m at 4.8%. DNP is really the utiutiu. Anyway, a buddy of mine is competing in a month and he’s currently at 7% bf(he’s about 190lbs) and he’d like to do it for two weeks. I understand that the lower one’s bodyfat % the greater amount needed (I responded very well to 4mg/kilo but I was also dieting)

Questions I have answered for DNP users

Are all of the losses on DNP fat losses?
You can?t ever say ALL in the scientific world, but it is the best we can get!

Animal, you have been a big help already. I’ve got some questions for ya. I am 195#, and plan on taking 200 mg in evening and 200mg before bed. I also plan on taking pyruvate and glycerol (via your recommendation). I’ll going to use a 8on/8off cycle.

Should I attempt to lift while on dnp?
Sure.

What dosage glycerol and pyruvate do you reccommend?
3 tablspoons a day on the G and 3g of the P

You said that you experienced an anabolic “burst” directly after coming off of dnp. Could this be contributed to your muscles reglycogenating themselves?
No, because I didn?t really get pumped, but strength went up.

or do you feel that this is genuine protein synthesis?
Yes, or nerve excitation/generation or a return of T3. Let me explain the nerve generation in more detail for a moment. When you do strength exercises of 5 reps or less you are training the nerves to fire more muscle cells and to fire those muscle cells in the sequence you want. Now, if we add DNP we are exhausting our muscle cells and they can?t fire as strongly. Result? Your nervous system trains more nerves to fire other muscle cells which had previously gone un or underused when energy stores were high. You are getting a nerve training session due to exhaustion! The more I think about it the more it is like those overtraining programs where you overtrain for a week and you get a rebound. That is what is happening except you are overtraining at the same weights due to the DNP.
Hehe. It is called overcompensation training and I?ll take it!

A user:
Found some info 'bout DNP “With even a low dosage, in the area of 3-5 mg/kg of body weight a day, it will rate your metabolic rate 30%. If this dosage is continued daily, it will raise your metabolism by 50%. At this rate you can burn about 1 lb. of fat a day.”

Animal:
Now, let’s think about this for a second. If metabolism can go from 30-50% that means there is a residual amount left over from the previous dose and therefore the 36hour clearance dosing schedule which I recommend. Furthermore, when I overdosed on 800mg I sweat for OVER 48 hours so this tells me that the half-life can be even longer in some circumstances. It is, nonetheless, up to you as to how you want to take it. If every 24 hours is tolerable for you, then do it.

A user:
That’s not what I’ve noticed. At present I’v even gained some weight. I’m 98 kg now. I don’t look a bit harder but maybe I shouldn’t expect that after only 4 days.
You WILL hold onto to water! You WILL be depleting carbs from the muscle that will make you look flat! Most WILL NOT notice the benefits until a week or two later upon cessation of DNP. Some see benefits right away, but they appear to already have a bodyfat below 10%.

A speculator wrote:
For a person that is highly active and on a calorie restricted diet, DNP will deplete ATP within a matter of days. When this happens your body temperature will go back to normal. The only thing you can do at this point is supplement with in the dosage area of about 150 mcg/day."

Animal:
Believe me, you will feel wasted (tired) and LOSE muscle on the regimen and the liver does not control oxidative phosphorylation in every cell. You will still be hot regardless of your T3 levels.

Question:
Won’t the conversion of T4-T3 come back and function again after discontinuing DNP administration?
Animal
Yes, and as long as you do some carbs at 600g a day for three days after.

Or do I have to look to get T3 as well?
Animal
Not really, if ATP was being ever totally depleted you would be cramping. Lack of ATP generation happens when you are what? DEAD!!! It is called rigomortis and if people who write right about DNP had an education or an inkling about body chemistry and process they would know this! Total ATP depletion resulting in death of the cell is not possible. There is some safety mechanism and I imagine it is via the fat cells, but you will not deplete your ATP unless you are an anorexic or dead.

User:
And isn’t a total lack of ATP what we want, so we can start burning fat instead of ATP?
Animal:

Wrong and this is not your fault, but again those who claim to be experts who are dispensing such disinformation. Once the ATP to ADP and to AMP is changed below a certain amount the cell gets it energy from another source which would be the fat. You are looking to burn the glycogen and then the fat is used. This does not mean ATP is gone!

Why is thermogenesis stopped if there isn’t any ATP?
Animal:
Read above and it is never stopped. DNP NEVER stops working unless the proton gradient is severely altered. Even in such a case, parts of the mitochondria can have one direction of proton gradient while another section can have a DIFFERENT proton flow!

User:
Is this why you want a break after one week? To load up with ATP so thermogenesis can start again?
Animal:
No, so you don’t feel like utiutiu all the time and so you can get the liver converting T4-T3 again

Is a one-week-break enough? Or maybe too short if I’m in a hurry.
You could do DNP for 2 weeks or more if you want.

Wouldn’t it be enough just to discontinue the DNP-cycle to let the liver start converting T4 to T3?
That is why you stop after a week!

Where are ATP-molecules stored?
In and/around the mitochondria and in the cytosol of the cell and ATP is attached to certain enzymes waiting for activation.

How much ATP do we have in storage?
That is a major calculation and I haven’t looked for an answer, but I don?t think it is important as you can never get rid of all of it.

A speculator:
“The administration of DNP, at a dose of 3.5 mg per kilo, increases the total production of heat by about 40%, from the 3rd or 4th day. This increase of the metabolism is due MOSTLY to an increase in the combustion of the fat and a LITTLE to combustion of carbohydrates.”
Any comments on this?
Animal:
Again, you are seeing a residual affect. The molecules that the mitochondria use for production of ATP can come from carbs or fat, but the important part is that it is not from muscle.

Another fact found in the same report as above:
“In prolonging the administration of the medication, one observes an increase of the tolerance of carbohydrates.”
Does this mean we get increased insulin-sensitivity?
That is a weird sentence and I don’t know what it means, but I think it means you will be more receptive to carbs. You now have increased your insulin sensitivity and this could explain the DNP users? craving for carbs while using DNP.
.
So when I eat carbs (I’ve noticed that I start to sweat then) the body starts burning fat?
No, the body burns excess ATP and food intake itself is thermogenic.

Why simple sugars? That means I should walk around eating candy all day?
Candy is not really a simple sugar as it usually has fat or fructose with it.
You want a simple sugar every so often to get some insulin rise and some fructose will help recarb the liver as fructose is about 4 times better at recarbing the liver than glucose. Glucose is, BTW, 2 times at good at recarbing muscle when compared to fructose.

What happens with the carbs?
They are burned and insulin release and helps change charge on the cells.

Insulin is secreted. I’ve noticed that. (If it wouldn’t I’d go glucose-high-'n-crazy.) Do I store carbs as glycogen?
AHAHA! So much for the speculators that say you have to do insulin!
You won’t have time to make glycogen and the glucose will go right to ATP production.

What about cataracts and skin lesions?
That is a long term chronic dose situation and why you take pyruvate.

Have you noticed anything?
Yes, your sweat smells bad, but no lesions. Another reason you want simple sugars or insulin is that DNP starts to make your vision blurry if you are on a low carb diet.

Animals? Analysis of someone else?s recommendations:

Comment
After 7 days, DNP dislodges T4 off the carrier proteins, allowing the T4 to be excreted rapidly.

Animal:
THIS IS A FUNCTION OF THE PRESENCE OF ATP. END OF DISCUSSION! This has been proven with many people who have used pyruvate which provides an easily usable energy source. Most users only stay on it 7 days so the point would be moot. Since you have depleted the carbs from the liver you are changing the ability of the liver to change T4 to T3. This happens with ANY diet within 7 days. With DNP you have inhibition of conversion via heat (small factor I believe) and via glycogen depletion. This loss of water due to glycogen depletion changes the osmolarity of the liver cells and inhibits the conversion of T4-T3. Now, with the concomitant loss of water you have a loss of charge which is what we are trying to control with the taurine dosing…

Comment
I have used T3, and recorded the average elevated body temperature at day 4 on DNP. After 7 days, the temp will decline, so I use T3 2X a day to restore the elevation.

Animal.
Really? Most people, including myself, hardly notice any temperature change. I used T3 at 50mcg up to 100mcg on day 5 and never felt worse or more run down than any other DNP experiments I have done.

Comment:
It really doesn’t matter how much or how long for the T3, because though excessive-looking, T3 blood level will be normal.

Animal:
This is NOT true because people have had their thyroid tested while on DNP and their thyroid levels were sky high. Excess thyroid can be responsible for what when calorie deprived? Muscle breakdown. Carbs are gone due to DNP. Your cells are going to be looking to scavenge energy so they are not going to have any protein synthesis because this requires energy. You are going to be in ketosis which is producing glucagon which is responsible for protein breakdown. You will, therefore, have no insulin which is responsible for anabolism of glycogen. You will have no blood sugar or liver glycogen left. Now what is going to happen?! Muscle breakdown. DNP is carb/fat specific and since there is no glycogen/glucose circulating due to high fat-low carbohydrate diet, where is the energy coming from? Ketones can’t be made into carbs and about the only source of carbs you are going to have is the glycerol molecule which results from fat breakdown which is minimal. Now throw your excess T3 on there. Hmmm? Sounds like a recipe for muscle breakdown to me.

Comment:
Besdies, you’ll get sick before you have to worry of being on T3 so long. Trust me, children: DNP for 7 days, and 7 off. You’ll be much healthier.

Reply.
I totally disagree! Many of us have permanently lowered body temps due to clen-T3 usage which many of the same moron gurus recommended even when using clen for 2-3 weeks. The thyroid is going to see excess T3 in the blood and do you think it is going to want to produce more T4 and T3 on its own? This is what I really don’t like about doing the T3, here. Yea, it is only for a week, but 2 weeks on clen which is not even T3 has fucked up many of us,. If your theory panned out then why couldn?t we do 1 week AS cycles or why have all the 2x2x2 cycles fallen into the pit of futility? I know we are talking different receptors, but they all still function via the negative feedback system.

Auxillary

(Consultation question)
After this Clen, DNP, and high fat diet experience I’m hoping to be down to around 7%BF. Which would leave me at about 165-170lbs. That is too small for me. I want to go on a cycle after that and try to put on a good 20lbs. I have a great diet for my cycle, so I know if I dont make the 20lbs gain I want its not because of nutrition. ( A problem i seem to always have). I wanted to know your thoughts on a cycle that I could really put on a good 20lbs. I know how much of your gains you keep depends on what you do prevent losses ( example: Clomid, and something to regulate cortisone levels, along with others, I have a gains keeper formula I plan to use). but If I do this I want to keep the majority of my gains. That?s why I wanted to include primo since you usually keep what you gain from primo.

Answer
Yea, but you don?t gain much and Eq or ganabol would be better as would fina.

Can you think of a good combo to add to primo for permanent MASS gains???
Answer
Test (Tp, TC, Te) or a trenbolone (fina, anibolan, parabolan). D-bol then fina always works nicely, too.

Maybe deca and sustanon or deca and omandren???
Answer:
Wouldn?t go with deca and sus and omna are more or less the same.

Any other s??? ? I have heard if you want to keep gains tests are not good to use
(enthanate, cyp etc.)
Answer:
BS. You have to know how to come off and not overtrain as you are coming off. Think about it. You have gotten stronger which is a result of nerve training. Now if you lift and let your muscles recover longer when off the AS you won?t lose your size!

. Do I have to take insulin while on DNP if I am taking equipoise and finaplix?
Answer:
No, not really and not if you are going to stay on only for a week at about 400mg or less DNP dose.

Do I have to take cytomel, clen or ECA stack while on DNP?
Answer:
I would take EC, but do the others after being careful to note that Clen and T3 will suppress your natural T3. Would be better to throw in tyramine and yohimbine or mazindol.

I have quite a bit of clen, and cytomel, but no ephedrine.
Answer:
You can sub in PPA or adipokinetix or pyruvate or nicotine or mazindol.
( I have never had a problem doing nicotine as a chew or as cigars and then quitting, but this is obviously not for all)

I didn’t understand if you said whether or not to start with a low dosage of DNP or not.
Answer:
I would if you have never done it before just to see what your tolerance is.

Question:
Also, you told me that I should not take cytomel while I am using> the DNP but to use it after the DNP. I was under the impression that DNP suppresses the thyroid and that I should use the cytomel while using the DNP so I will keep burning fat. Would you please explain this to me?

Answer:
DNP alters the blood and liver glucose levels and THIS is what keeps the liver from converting T4-T3. If you eat normally this won’t happen so drastically and T3 will return to normal soon after stopping DNP. Now, if you have low Blood sugar levels and you add T3 you are going to lose muscle as well as is seen in people that are on low calorie diets who supplement T3. T3 without the right energy and hormones stores is disastrous to muscle.

Other dieting stuff

ketotifen and upgrade of clen receptors, but you need 10 1mg tabs of ketotifen a day which will make you hungry and sleepy.

I was thinking of the efficacy or more like the ?sense of adding t3 toDNP.
Well, if you are adding-T3 you are going to have a lot of T4 AND T3 floating around and the thyroid is going to read that as an exess and shut down T3 and T4 production.

Other cycles for DNP use

Why not do DNP in even smaller doses like that of ephedrine up to 100mg or so?. It will speed up the metabolism and cause a loss of weight without all the discomfort and t4-t3 conversion shutdown. Furthermore, by speeding up the metabolism it may help upgrade steriod receptors and clen receptors with much less discomfort for the user.
DNP seems to upgrade clen receptor sites as well as steroid receptor sites.
The rebound for the AS upgrade is only known from anecdotal feedback from myself and others, but if you increase the metabolism of the cell it only stands to reason that you are going to decrease the time it takes to regenerate the receptor sites. The ATP depletion and opening of ATP channels is also likely to be playing a part in these benefits as well, but that is research that probably won?t be done. So the channel part in the upgrade is just speculation.

Some may need to build-up the dose to start. I had to do it for 3 days and then do 800mg before I started to sweat like a pig for 2 days! Now moderate doses of 200mg make me sweat although not to the same extent, but at least I know I?ve taken it. Kinda like bee stings. You don’t have any allergic reaction until one sting and then you get the benefits (problems) from one sting. I do know of a case with a women that had similiar results and said it wasn’t working and even talked to w8 about it, but then she ordered more so this has to be what the problem was/is.

Response to someone that was throwing up and nauseated from DNP use.

You have low blood sugar!
This is a classic symptom which can occur with diabetics who use too much insulin. When I use too much insulin and then ride too soon after I would see spots. DNP caused me to see spots as well. DNP depletes all your blood sugar and glycogen first and this will give you low blood sugar, nausea, etc. That is why you want to get your insulin up with glucose once or twice a day on DNP and DO NOT do high fat diets on DNP. W8 will disagree with me on this, but when you look at the actions happening at the liver you will realize that high fat diets just extenuates the slowdown of T4 to T3 conversion.

Q: But when I?m off I?m gonna keep carbs almost non-existant to burn more fat, and take Adipokinetix to avoid a rebound off of the DNP.
A: DNP stops conversion of T4-T3 due to carb depletion so you may not want to do that although the Adipo is good. DNP, Adipo, clen, ECA, DNP would be a good way to go or do the clen right before a week of DNP, but only for a week.

Q: IM OFF MY CYCLE IN AWEEK. THEN IM GONNA TAKE CLOMID, PS,NOLVADEX, TO AVOID A LOSS INGAINS. THEN ITS CUTTING TIME.
A: Nolvadex and clomid are redundant, do one or the other. PS sucks, but if you already have it, then use it

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